301482
Multiple Sclerosis,Posit Science,Trial,Positive Result
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50
date
desc
1
24830
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Ziccardi, Stefano, Tom Fuchs, Michael G Dwyer, Robert Zivadinov, Hanneke E Hulst, Massimiliano Calabrese, and Ralph HB Benedict. 2023. “Cognitive Phenotypes Predict Response to Restorative Cognitive Rehabilitation in Multiple Sclerosis.” Multiple Sclerosis Journal, 13524585231208332. https://doi.org/10.1177/13524585231208331.
Chiaravalloti, Nancy D., Silvana L. Costa, Nancy B. Moore, Kristen Costanza, and John DeLuca. 2022. “The Efficacy of Speed of Processing Training for Improving Processing Speed in Individuals with Multiple Sclerosis: A Randomized Clinical Trial.” Journal of Neurology 269 (7): 3614–24. https://doi.org/10.1007/s00415-022-10980-9.
Vilou, Irini, and Christos Bakirtzis. 2020. “Computerized cognitive rehabilitation for treatment of cognitive impairment in multiple sclerosis: an explorative study.” Journal of Integrative Neuroscience 19 (2): 341–47. https://doi.org/10.31083/j.jin.2020.02.35.
Shaw, Michael, Giuseppina Pilloni, and Leigh Charvet. 2020. “Delivering Transcranial Direct Current Stimulation Away from Clinic: Remotely Supervised TDCS.” Military Medicine 185 (Supplement_1): 319–25. https://doi.org/10.1093/milmed/usz348.
Fuchs, Tom A., Stefano Ziccardi, Ralph H. B. Benedict, Alexander Bartnik, Amy Kuceyeski, Leigh E. Charvet, Devon Oship, et al. 2020. “Functional Connectivity and Structural Disruption in the Default-Mode Network Predicts Cognitive Rehabilitation Outcomes in Multiple Sclerosis.” Journal of Neuroimaging 30 (4): 523–30. https://doi.org/10.1111/jon.12723.
Fuchs, Tom A., Stefano Ziccardi, Michael G. Dwyer, Leigh E. Charvet, Alexander Bartnik, Rebecca Campbell, Jose Escobar, et al. 2019. “Response Heterogeneity to Home-Based Restorative Cognitive Rehabilitation in Multiple Sclerosis: An Exploratory Study.” Multiple Sclerosis and Related Disorders 34 (September): 103–11. https://doi.org/10.1016/j.msard.2019.06.026.
Barker, Lindsay, Brian C. Healy, Emily Chan, Kaitlynne Leclaire, and Bonnie I. Glanz. 2019. “A Pilot Study to Assess At-Home Speed of Processing Training for Individuals with Multiple Sclerosis.” Multiple Sclerosis International 2019. https://pubmed.ncbi.nlm.nih.gov/31275652/.
Charvet, Leigh E., Jie Yang, Michael T. Shaw, Kathleen Sherman, Lamia Haider, Jianjin Xu, and Lauren B. Krupp. 2017. “Cognitive Function in Multiple Sclerosis Improves with Telerehabilitation: Results from a Randomized Controlled Trial.” PLOS ONE 12 (5): e0177177. https://doi.org/10.1371/journal.pone.0177177.