The IHAMS Study

First Study to Show Brain Training Outperforms Crossword Puzzles

A study known as IHAMS pitted a BrainHQ exercise against crossword puzzles. Researchers at the University of Iowa, reporting in the peer-reviewed journal PLOS ONE found that the group using the computerized exercise for just 10 hours had significant gains in cognitive function, while the group doing crosswords on the computer for an equal amount of time had no significant improvements. The study also broke new scientific ground in comparing older and younger users, users on their own at home against users in a supervised setting, and users spending varying amounts of time on the brain fitness exercise.

Study Design and Goals

The NIH-funded IHAMS was designed to improve on the design of the ACTIVE study in two main ways—by including younger participants (ages 50 or older) and by using an active control group (crossword puzzles). IHAMS used a BrainHQ exercise that improves speed of processing and useful field of view (called Double Decision in BrainHQ).

The researchers separated 681 generally healthy people into four groups. One group was given computerized crossword puzzles, while the other three groups did the brain training exercise in different settings: on their own at home, in a supervised setting, or in a supervised setting with four extra hours of “booster” training. Researchers also compared participants aged 50-64 against those aged 65-plus. All groups were assessed prior to the start of the study, at 6 to 8 weeks into the study, and then at 12 months.

The IHAMS study had two main goals, one of which was to determine if brain training was superior to “standard” activities for brain improvement—in this case, crossword studies—and the other of which was to see if the effects were similar in the younger group of people and the older group of people

Superior Results from BrainHQ Training

Initial results showed that participants who used the BrainHQ exercise showed significantly larger improvements in their cognitive capabilities on several standard neuropsychological tests of cognitive functioning than did the participants who trained on crossword puzzles. The improvements in cognitive function were the same whether the brain exercises were done in the monitored clinical setting or in the participant’s home. These positive changes were observed in as little as 8 weeks, and were sustained over 12 months. The sub-group of participants that received an extra four hours of training posted even greater gains.

The improvements for the younger participants were just as large as those for the older participants, indicating that brain training could and should be started sooner rather than later. In addition, the researchers noted that people who did the exercises on their own at home did just as well as people who did them under supervision. This indicates that the training can be widely deployed at low cost and to remote areas.

The IHAMS Study Design

  • Prospective: The study enrolled people and then followed them over time. This is a better study design than looking at what has happened to people in the past, because scientists can measure outcomes (like amount of cognitive training, or cognitive function) directly, rather than having to rely on people’s recollection of what happened to them years ago.
  • Randomized: The study randomly assigned people to one of the cognitive training groups or to the crossword puzzle group. This ensures that the benefits seen in a group are only the result of being in that group and doing the cognitive training, and aren’t the result of a scientist putting all the people who share a characteristic (like they have good cognitive function, or they are friends) into one group.
  • Active Controlled: The cognitive training groups were compared to an active control group doing crossword puzzles. This helps ensure that the benefits seen in a cognitive training group are not just due to getting practice on the cognitive test, or because people expected to improve because they were doing something cognitively stimulating.
  • Blinded: The scientists measuring cognitive function were not told which group a study participant was assigned to. This helps make sure that those scientists didn’t unconsciously give higher cognitive function scores to people doing the cognitive training program, in the hope the study would be successful.

Further Reading

You can read the main IHAMS paper here. Remember, the term “speed training” and “Road Tour” in this paper refers to the training program now called “Double Decision” in BrainHQ.