Until recently, it was widely believed that the brain was hardwired from childhood and resistant to any remodeling in adults. Breakthrough research and clinical practice has recently shown that our brains are remarkably plastic across the human life span. Neuroplasticity accounts for functional self-improvement at any age, often remarkable recoveries from brain injury or stroke, demonstrated impacts of brain exercise for sustaining our brain health, and for successful supportive therapies in patients facing age-related dementia. Strategies for employing neuroplasticity science for human benefit are rapidly emerging. One of the pioneers in this field is neuroscientist Michael Merzenich, a professor emeritus at UC San Francisco.